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    Atomic-level cancer studies – a new challenge to distal interdisciplinary science
    (Oficyna Wydawnicza AFM, 2023) Taran, Katarzyna Anna
    Background: Nowadays, the amount of cross disciplinary research in many branches of science is growing dynamically. Multidisciplinary, interdisciplinary and transdisciplinary evaluations are being carried out. Scientific progress, in combination with the development of knowledge and new technical discoveries, allows the most complex problems to be considered in an innovative way, which results in original solutions, not present in the previous, more traditional understanding. Materials and methods: We reviewed the current data on the evaluation of pathological tissues using current mass spectrometry methods, including advanced isotope ratio mass spectrometry in the first known atomic level cancer studies. Results: The first attempts to estimate the stable isotope ratio in pathological tissues appeared as a potentially new method of understanding the biology of cancer. The changes in stable isotope concentration showed the relationship with the fundamentals of cancer – its promotion stage, and the mechanisms of its progression as well as its relationship to the standard prognostic biomarkers. The advanced multidisciplinary analysis of the results of isotope ratio assessment in cancer studies culminated in the creation of ‘The Revolve(r) Heavy Nitrogen Theory of Death’, which explains the phenomena of the proliferation force of cancer cells. Conclusions: Stable isotope profiling performed using the highly advanced and creditable isotope ratio mass spectrometry approach reveals the previously unknown area of pathological tissue biology. Overcoming interdisciplinary barriers opens a new branch of medical studies with a potential clinical application. The intriguing results of the first attempts and potential clinical implications should form the basis of the next atomic-level cancer studies projects.
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    Medicine and Public Health 2023, Vol. 1, Number 1
    (Oficyna Wydawnicza AFM Uniwersytetu Andrzeja Frycza Modrzewskiego w Krakowie, 2023) Zuzak, Tomasz Zbigniew; Bogaczyk, Anna; Januszek, Natalia; Januszek, Sławomir; Kluz, Tomasz; Taran, Katarzyna Anna; Aksędowski, Krzysztof; Komorowski, Andrzej L.; Korneta, Krzysztof; Zavatskyi, Ruslan; Wąsik, Magdalena Maria; Bazielich, Antoni Wiktor; Sielski, Peter; Senderek, Tomasz; Komorowski, Artur; Solecki, Krzysztof; Miklaszewski, Krzysztof
    Introduction: "It is with great pleasure that I invite readers to browse through the first issue of our journal “Medicine and Public Health”. It is not surprising that as the articles in this issue were submitted not long after the most intense period of the pandemic, we notice a significant number of articles dealing with different aspects of the COVID pandemic. It heavily influenced virtually all aspects of healthcare, hence articles about its impact on areas such as cancer screening and emergency surgery are included. There are also several interesting case reports ranging from an atypical presentation of gallbladder cancer, an atypical Amyand hernia, to the rare congenital malformation situs inversus. In addition, the reader will have the opportunity to consider the difficulties that accompany the differential diagnosis of a kidney mass and iliac crest mass in the section concerning images in clinical medicine. All in all, I sincerely believe that the mix of articles prepared for this issue will meet the high expectations of our readership. And if this is so, I can assure you that we are already working on the next, and hopefully even more interesting issue of our journal."(...)