Przeglądaj wg Słowo kluczowe "zinc"

Teraz wyświetlane 1 - 2 z 2
  • Miniatura
    Pozycja
    Anti-inflammatory properties of cantharellus cibarius from in vitro culture enriched in zinc
    (Polish Pharmaceutical Society, 2018) Gudula-Argasińska, Joanna; Grzywacz, Agata; Krakowska, Agata; Opoka, Włodzimierz; Muszyńska, Bożena
    Cantharellus cibarius Fr. (Basidiomycota), commonly known as Chanterelle, is one of the most valued and currently most often collected species of edible mushrooms in Europe, Asia, Africa, and the northern USA. Cantharellus genus (chanterelles) includes seventy species, seven of which are noted in Europe. Due to the valuable and biologically active metabolite content in the fruiting bodies, C. cibarius was selected for the study. The combinations of carbohydrates, amino acids, unsaturated fatty acids, and vitamins revealed the nutritional, in particular, anti-inflammatory properties of this species. Zinc (Zn) is one of the microelements present in significant quantities in the fruiting bodies and biomass from in vitro cultures of edible mushrooms. Zn plays a crucial role as an anti-inflammatory agent. This paper presents a study on investigation of the pro- or antiinflammatory properties of mushroom extracts from fruiting bodies and biomass from in vitro culture of C. cibarius enriched in Zn. As an additive to the modified Oddoux liquid medium, on which in vitro C. cibarius cultures were grown, the following two compounds were used: zinc sulfate and zinc hydroxyaspartate. In order to compare which complex will most effectively increase the anti-inflammatory activity of C. cibarius, inorganic and organic compounds were used. Both zinc salts were used in such quantities that the calculated additive amount of zinc into the culture media was the same. Control cultures were represented by in vitro cultures on Oddoux medium grown without the supplementation of zinc compounds. In addition, we studied which source of zinc is best for enhancing anti-inflammatory properties in A549 (Human Lung Epithelial Carcinoma, ATCC) cell models activated with lipopolysaccharide (LPS) to induce inflammation. Results of the study showed the important role of zinc during inflammation in the lung epithelial cells. Cantharellus cibarius in vitro cultures with high ability to accumulate zinc enabled the precise application of zinc compounds at a known concentration that may influence their immuno-modulatory properties.
  • Miniatura
    Pozycja
    The role of zinc in the pathogenesis and treatment of central nervous system (CNS) diseases. implications of zinc homeostasis for proper cns function
    (Polish Pharmaceutical Society, 2014) Tyszka-Czochara, Małgorzata; Grzywacz, Agata; Gdula-Argasińska, Joanna; Librowski, Tadeusz; Wiliński, Bogdan; Opoka, Włodzimierz
    Zinc, the essential trace element, is known to play multiple biological functions in human organism. This metal is a component of many structural as well as regulatory and catalytic proteins. The precise regulation of zinc homeostasis is essential for central nervous system and for the whole organism. Zinc plays a significant role in the brain development and in the proper brain function at every stage of life. This article is a review of knowledge about the role of zinc in central nervous system (CNS) function. The influence of this biometal on etiopathogenesis, prevention and treatment of selected brain diseases and disorders was discussed. Zinc imbalance can result not only from insufficient dietary intake, but also from impaired activity of zinc transport proteins and zinc dependent regulation of metabolic pathways. It is known that some neurodegenerative processes are connected with zinc dyshomeostasis and it may influence the state of Alzheimerís disease, depression and ageing-connected loss of cognitive function. The exact role of zinc and zinc-binding proteins in CNS pathogenesis processes is being under intensive investigation. The appropriate zinc supplementation in brain diseases may help in the prevention as well as in the proper treatment of several brain dysfunctions.