Prostate cancer is the second most frequently diagnosed cancer in men worldwide, after lung cancer. In the early stages in Poland it is usually detected accidentally. Despite effective treatment methods, a large group of men with symptoms of disseminated cancer process become patients of palliative care. This chapter reports the case of a man, aged 89, residing in an inpatient hospice with a diagnosis of advanced prostate cancer (Gleason Score 5 + 3 = 8), with bone metastasis, who had previously been treated with hormone therapy. At the time of nursing care, the patient scored ten points on the Barthel Index, seven points on the NRS pain scale, and nineteen points on the MNA nutrition scale and had a BMI of 20.76. He showed incomplete acceptance of the disease (twenty points on the AIS scale) and features of mild depression (seventeen points on the Beck depression scale). The main health problems/nursing diagnosis are pain, swelling, difficult urination, constipation, weakness and malnutrition. End-stage prostate cancer has a strong impact on the ability to perform daily activities and limits independence. Caring for cancer patients requires nurses to be highly qualified and skilled, as well as capable of showing understanding and compassion.