This paper focuses on analysis of structural competitiveness of Polish trade with USA in face of the negotiation of Transatlantic Trade and Investment Partnership (TTIP) between EU and US. Process is discussed in the context of wealth-effect of international trade as well as overregional international integration. Appart from analytical debate, this paper attempts to determine challenges and chances for Polish foreign trade with US and with EU countries as well as the economy in a view of modern-factor-imports from US. Introduction off ers an insight into determinants and data of Polish intra-industry trade.