Amyotrophic lateral sclerosis (ALS) is one of the most serious neurodegenerative diseases. It is a primary degenerative disease of the nervous system with a progressive course. ALS is a disease of unknown aetiology. For patients and families, the greatest cruelty of this disease is the fact that as it progresses, muscle atrophy and paresis occur. In the advanced stage, the sufferer is completely immobilised, unable to move despite full mental capacity and awareness. Although the disease is incurable, many of its symptoms can be alleviated, and the goal of therapy should be to improve the quality of life and maintain the patient’s independence for as long as possible. The aim of this study is to develop a model of care for a patient with ALS using the International Classification for Nursing Practice (ICNP®). The study is based on an individual case study of a patient with ALS. Information for the development of the nursing model was collected on the basis of an interview with the patient and her family, observation of the patient, analysis of medical documentation (patient’s medical history, individual patient’s order card), laboratory test results, assessment using scales (ALSFRS-R Scale, Barthel Index, Norton Scale), and measurements (blood pressure, pulse, temperature, and saturation). According to the model of individual nursing care, nursing diagnoses were made in accordance with the assumptions of the ICNP®, goals of care, planned nursing interventions and assessment of nursing care. This chapter aims to recognise the main health problems faced by the patient and her family. The nursing actions taken facilitated the care of the patient and improved the quality of her life that of her family.