The paper aims at analysing the determinants of regional economic integration in Sub-Saharan Africa in relation to the European model of integration, perceived as a benchmark for the region. The paper employs analytic-descriptive analysis, using national and international literature sources and statistical data of the United Nations Conference on Trade and Development – UNCTAD. Research results show that regional integration processes in Africa are determined by natural conditions, economic and political determinants, as well as by adopted model of integration. As integration effects in Africa prove to be highly unsatisfactory, a critical review of adopted integration model seems to be necessary. International institutions should also verify their approach to African integration in order to provide this continent with an optimal balance between local regionalism and economic globalization.