A relation between USA and Egypt are especially important in the scope of the security and stabilization process in Middle East and reflects on the whole world. According to the deep changes in many countries of Middle East and North Africa, started by the Arab Spring at the beginning of 2011, US policy had to transform, and have to be adjusted to the new circumstances and Egypt is particular important for the USA interests in the area. To achieve this, a deep analysis of the situation in Egypt is needed and also clear picture of the real stance of the main powers in this country. The situation when USA bases only on the support of the despotic rulers or just the leading parties is not acceptable for the future relations between USA and Egypt. If Americans wants to keep it’s influence on the Middle East, the new policy of dialogue, partner relations and respecting peoples will is have to be introduced.