Diagnostyka chorób nowotworowych skóry na podstawie oznaczenia ekspresji metaloproteinaz

Uproszczony widok
dc.contributor.authorGoździalska, Anna
dc.contributor.authorGawędzka, Anna
dc.contributor.authorBrzewski, Paweł
dc.contributor.authorWojas-Pelc, Anna
dc.contributor.authorJaśkiewicz, Jerzy
dc.date.accessioned2014-11-19T12:50:51Z
dc.date.available2014-11-19T12:50:51Z
dc.date.issued2010
dc.descriptionPraca recenzowana / peer-reviewed paperpl_PL
dc.description.abstractMatrix metalloproteinases (MMPs) are zinc- dependent endopeptidase. A characteristic feature of MMPs is the ability of degradation of at least one component of the extracellular matrix (ECM). Degradation of ECM components like collagen proteins, proteoglycans and laminins leads to change in tissue structure, which enables the migration of tumor cells. Basal cell carcinoma (BCC) is the most common malignant tumor of the skin. BCC is derived from cells of the basal layer of the epidermis. Basal cell carcinoma is characterized by a slight ability to metastases. BCC is most common in Caucasians and the main cause of this type of tumor is the solar radiation. The aim of this study was to determine the expression of mRNA for MMP-2 and MMP-9 in basal cell carcinoma tissue and bordering healthy skin tissue (control sample). Both, examined and control tissues, were taken from the same patients. Skin tissues were obtained from 15 patients diagnosed as BCC nodularis skin cancer. Using the method of RT-PCR showed signifi cant increase in expression of mRNA for MMP-2 and MMP-9 in tumor tissue compared to non tumor skin tissue. It can be assumed that the molecular study of MMPs expression in skin tissue may be a useful and complementary diagnostics test in histopathologic diagnosis of skin cancer. Diagnostic tests, complemented with molecular markers, may allow for precise definition of the border margin of excised tumor, which is an important prognostic factor.pl_PL
dc.identifier.citationW: Interdyscyplinarne aspekty nauk o zdrowiu. (red.) Grażyna Dębska, Jerzy Jaśkiewicz. Kraków: Oficyna Wydawnicza AFM, 2010, s. 41-53.pl_PL
dc.identifier.isbn978-83-7571-105-9pl_PL
dc.identifier.urihttp://hdl.handle.net/11315/740
dc.language.isoplpl_PL
dc.publisherOficyna Wydawnicza AFMpl_PL
dc.rightsUznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/pl/*
dc.subjectmetalloproteinases (MMPs)pl_PL
dc.subjectbasal cell carcinoma (BCC)pl_PL
dc.subjectmetaloproteinazypl_PL
dc.subject.otherKosmetologiapl_PL
dc.subject.otherMedycynapl_PL
dc.subject.otherZdrowiepl_PL
dc.titleDiagnostyka chorób nowotworowych skóry na podstawie oznaczenia ekspresji metaloproteinazpl_PL
dc.typeFragment książkipl_PL
Pliki
Oryginalne pliki
Teraz wyświetlane 1 - 1 z 1
Miniatura
Nazwa:
Gozdzialska_Gawedzka_Brzewski_Wojas-Pelc_Jaskiewicz_Diagnostyka_chorob_nowotworowych_skory_2010.pdf
Rozmiar:
243.3 KB
Format:
Adobe Portable Document Format
Pobierz
Licencja
Teraz wyświetlane 1 - 1 z 1
Brak miniatury
Nazwa:
license.txt
Rozmiar:
52 B
Format:
Item-specific license agreed upon to submission
Opis:
Pobierz
Kolekcje
3.2 Fragmenty książek