PGT-A in POSEIDON Patients - perspectives and limitations
| dc.contributor.author | Wyroba, Jakub | |
| dc.contributor.author | Barszcz, Maria | |
| dc.contributor.author | Fajt, Iwona | |
| dc.contributor.author | Kochan, Joanna | |
| dc.date.accessioned | 2026-09-14T12:38:34Z | |
| dc.date.available | 2026-09-14T12:38:34Z | |
| dc.date.issued | 2025-12-10 | |
| dc.description.abstract | Abstract: „Objective: The aim of this study was to determine the likelihood of being able to perform PGT-A, and its results, in each POSEIDON group compared to their age-matched non-POSEIDON group. Methods: This was a retrospective study of 4 groups of POSEIDON patients (n=824) who underwent intracytoplasmic sperm injection (ICSI) The controls were non-POSEIDON patients in two age groups (<35 and ≥35 years old; n=360). Results: The non-POSEIDON <35Y group had the highest number of embryos at the blastocyst stage that could be used for PGT-A (5.1±2/cycle), and the POSEIDON IV group had the fewest (0.6±0.3/cycle). Significantly fewer blastocysts were PGT-A tested in the groups with no indications for PGT-A (i.e. POSEIDON I (26%) and III (28%) and non-POSEIDON <35Y (39%)), compared to the groups with indications (i.e. POSEIDON II (69%), and IV (67%) and non POSEIDON ≥35Y (72%)). The euploidy rate was similar between groups without PGT-A indications (59%-64%) and between groups with indications (35-41%), but was significantly lower in groups with indications (p<0.001). Conclusions: POSEIDON patients are as willing to undergo PGT-A testing as non-POSEIDON patients, despite the poor prognosis. However, the final PGT-A result is very low compared to that in non-POSEIDON patients of the same age. Failure is usually caused by the inability to perform the blastocyst biopsy due to a lack of oocytes or blastocyst-stage embryos, and to a low rate of euploidy in groups ≥35Y.”(…) | |
| dc.identifier.citation | JBRA Assisted Reproduction 2025, Vol. 29, Issue 4, s. 608-614 | |
| dc.identifier.doi | doi: 10.5935/1518-0557.20250037 | |
| dc.identifier.issn | 1518-0557 | |
| dc.identifier.uri | https://hdl.handle.net/11315/31630 | |
| dc.language.iso | en | |
| dc.publisher | SBRA - Associação Brasileira de Reprodução Assistida | |
| dc.rights | Copyright 2025 - JBRA Assisted Reproduction - All rights reserved | |
| dc.subject | PGT-A | |
| dc.subject | POSEIDON | |
| dc.subject | ICSI | |
| dc.subject.other | Medycyna | |
| dc.subject.other | Zdrowie | |
| dc.title | PGT-A in POSEIDON Patients - perspectives and limitations | |
| dc.type | Artykuł |