Introduction: More and more cases of Parkinson’s disease are diagnosed each year. Currently, nearly 6 million people suffer from it. Those affected by the disease are forced to make changes in many areas of their lives. Aim: The aim of this study is to identify the relationship between the assessment of the level of acceptance of the disease and the quality of life of patients with Parkinson’s disease. Material and methods: The study included 108 people with Parkinson’s disease. The research tool was a self-administered survey questionnaire and questionnaires: WHOQOL-BREF and Acceptance of Illness Scale (AIS). Results: Respondents experienced communication problems, fewer friends and social withdrawal. A large percentage of patients have problems related to sleep disorders, mood swings and depressive disorders. More than 60% of respondents were dissatisfied with their quality of life and health. The level of acceptance of the disease was low (AIS: 16.81). Conclusions: Parkinson’s disease negatively affects every sphere of life. The level of acceptance of the disease and quality of life were at a low level and independent of the duration of the disease. There is no connection between quality of life and the degree of acceptance of the disease.