1.2 Artykuły z wydawnictw zewnętrznych

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http://hdl.handle.net/11315/20648

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Przeglądaj 1.2 Artykuły z wydawnictw zewnętrznych wg Temat "Farmakologia"

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    Comparative multi-analytical characterization of lipid fractions from three cockroach species - Blaptica dubia, Gromphadorhina portentosa, and Periplaneta lateralis
    (Elsevier, 2026-04-11) Kowalczewski, Przemysław Łukasz; Kucharski, Jan Jakub; Ostrowska-Ligęza, Ewa; Grygier, Anna; Kmiecik, Dominik; Kamińska, Wiktoria; Siger, Aleksander; Dwiecki, Krzysztof; Siejak, Przemysław; Radzikowska-Kujawska, Dominika; Baranowska, Hanna Maria
    This study presents a comprehensive, multi-analytical characterization of lipid fractions extracted from three cockroach species: Blaptica dubia, Gromphadorhina portentosa, and Periplaneta lateralis, with the aim of elucidating interspecies differences in fatty acid composition, molecular organization, and physicochemical behavior. Lipid fractions were analyzed using gas chromatography, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), low-field nuclear magnetic resonance (LF NMR) relaxometry, and Langmuir monolayer techniques. All oils were dominated by monounsaturated fatty acids, particularly oleic acid; however, marked differences were observed in the SFA/MUFA/PUFA balance, iodine values, thermal transitions, and interfacial properties. B. dubia oil exhibited the most balanced fatty acid profile and the most compact and viscoelastic monolayers, indicating a structurally stable lipid system. G. portentosa oil was characterized by the highest tocopherol content and enhanced oxidative resistance, whereas P. lateralis oil showed the highest degree of unsaturation accompanied by increased molecular mobility. The applied analytical techniques revealed distinct lipid structuring and stability patterns across species, demonstrating that cockroach-derived oils represent chemically and structurally diverse lipid matrices. These findings provide fundamental physicochemical insight into insect-derived lipids and establish a reference framework for future studies addressing technological performance, stabilization strategies, or regulatory assessment pathways.
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    From Phenolic Profile to Gut Function: Comparative Effects of Region-Specific Shilajit on Selected Culturable Intestinal Microbial Groups and β-Glucuronidase Activity—A Preliminary Study
    (MDPI, 2026-06-21) Kamgar, Elham; Gumienna, Małgorzata; Górna-Szweda, Barbara; Kačániová, Miroslava; Kowalczewski, Przemysław Łukasz; Zembrzuska, Joanna
    Abstract: "Shilajit is a complex natural phytomineral substance whose composition and biological activity may vary depending on geographical origin. This study compared three commercially available Shilajit samples from Russia (S1), Nepal (S2), and Iran (S3) in terms of phenolic acid profile, antimicrobial activity, and their effects on selected intestinal microorganisms and β-glucuronidase activity after simulated gastrointestinal digestion. The samples differed markedly in their phenolic composition, with S3 showing the highest total content of the quantified phenolic acids. All samples exhibited antimicrobial activity, although their intensity depended on the microorganism tested. The in vitro digestion model revealed clear sample-dependent effects: S2 showed the lowest net β-glucuronidase activity and the most beneficial modulation of Lactobacillus and Bifidobacterium, whereas S1 exerted the strongest suppressive effect on Escherichia coli. In contrast, S3, despite the richest phenolic profile, showed the highest β-glucuronidase activity. These findings indicate that the biological activity of Shilajit depends not only on the quantified phenolic acids but also on the broader, region-specific chemical matrix of the material."