1.2 Artykuły z wydawnictw zewnętrznych

Stały URI dla kolekcji

http://hdl.handle.net/11315/20648

Przeglądaj

Teraz wyświetlane 1 - 20 z 39

Age-Dependent Association Between Insomnia and Body Mass Index Among Young Women: Evidence from a Cross-Sectional Study
(Licensee MDPI, Basel, Switzerland, 2025-12-16) Merklinger-Gruchała, Anna; Goździalska, Anna; Bień, Agnieszka; Grzesik-Gąsior, Joanna
Abstract: "Sleep disturbances, particularly insomnia, are increasingly recognized as important determinants of health. Previous studies have shown bidirectional associations between sleep quality and obesity. Limited evidence exists on the modifying role of age in the relationship between insomnia symptoms and body mass index (BMI) among women. This study aimed to evaluate the association between insomnia symptoms and BMI in women, with a specific focus on the potential effect of age. Methods: A cross-sectional study was conducted among 72 female nursing students aged 21–48 years. Data were collected via an online questionnaire including demographic, occupational, and anthropometric variables, as well as the Athens Insomnia Scale (AIS) to assess insomnia symptoms. BMI was calculated based on self-reported weight and height. Logistic and multiple linear regression models were used to evaluate the relationship between AIS scores and BMI and age. Results: Overall, insomnia severity was not directly associated with BMI in the full sample (p = 0.55). However, a significant interaction between insomnia symptoms and age was observed (p = 0.02). Among women aged ≥37 years, higher AIS scores were positively associated with BMI (β = 0.59; p = 0.06), whereas this association was absent in younger participants. Conclusions: Insomnia symptoms showed a trend toward a positive association with higher BMI, primarily among older women, suggesting an age-dependent relationship between sleep disturbances and body weight. Screening for sleep problems and promoting sleep hygiene could serve as simple, low-cost preventive strategies for maintaining metabolic health in women."(...)
Anti-inflammatory properties of cantharellus cibarius from in vitro culture enriched in zinc
(Polish Pharmaceutical Society, 2018) Gudula-Argasińska, Joanna; Grzywacz, Agata; Krakowska, Agata; Opoka, Włodzimierz; Muszyńska, Bożena
Cantharellus cibarius Fr. (Basidiomycota), commonly known as Chanterelle, is one of the most valued and currently most often collected species of edible mushrooms in Europe, Asia, Africa, and the northern USA. Cantharellus genus (chanterelles) includes seventy species, seven of which are noted in Europe. Due to the valuable and biologically active metabolite content in the fruiting bodies, C. cibarius was selected for the study. The combinations of carbohydrates, amino acids, unsaturated fatty acids, and vitamins revealed the nutritional, in particular, anti-inflammatory properties of this species. Zinc (Zn) is one of the microelements present in significant quantities in the fruiting bodies and biomass from in vitro cultures of edible mushrooms. Zn plays a crucial role as an anti-inflammatory agent. This paper presents a study on investigation of the pro- or antiinflammatory properties of mushroom extracts from fruiting bodies and biomass from in vitro culture of C. cibarius enriched in Zn. As an additive to the modified Oddoux liquid medium, on which in vitro C. cibarius cultures were grown, the following two compounds were used: zinc sulfate and zinc hydroxyaspartate. In order to compare which complex will most effectively increase the anti-inflammatory activity of C. cibarius, inorganic and organic compounds were used. Both zinc salts were used in such quantities that the calculated additive amount of zinc into the culture media was the same. Control cultures were represented by in vitro cultures on Oddoux medium grown without the supplementation of zinc compounds. In addition, we studied which source of zinc is best for enhancing anti-inflammatory properties in A549 (Human Lung Epithelial Carcinoma, ATCC) cell models activated with lipopolysaccharide (LPS) to induce inflammation. Results of the study showed the important role of zinc during inflammation in the lung epithelial cells. Cantharellus cibarius in vitro cultures with high ability to accumulate zinc enabled the precise application of zinc compounds at a known concentration that may influence their immuno-modulatory properties.
Assessment of molecular dynamics in natural Shilajit using low-field NMR relaxometry for geographical traceability
(De Gruyter, 2026-01-19) Kamgar, Elham; Baranowska, Hanna Maria; Kaykhaii, Massoud; Nowicki, Marcin; Kowalczewski, Przemysław Łukasz; Zembrzuska, Joanna
Shilajit (Mumijo) is a phytomineral exudate known for its therapeutic potential, traditionally used in Ayurvedic medicine. Its molecular composition and consequently its therapeutic properties are influenced by geographical origin. Low-field nuclear magnetic resonance (LF NMR) offers a non-destructive tool to assess the molecular behavior of Shilajit rapidly and non-destructively. Twelve raw Shilajit samples from five regions (Iran, India, Nepal, Russia, and Kyrgyzstan) were analyzed using LF NMR at 15 MHz. Longitudinal magnetization relaxation (T1) and transverse magnetization relaxation (T2) relaxation times were measured using an inversion-recovery and Carr–Purcell– Meiboom–Gill pulse sequence, respectively. Three distinct relaxation behavior groups were identified. Group I showed only T1 (solid samples with undetectable T2), group II exhibited single T1 and T2 (moderately viscous, hydrated samples), while group III revealed biphasic T2 relaxation (indicating proton heterogeneity). Clear differences in relaxation profiles were observed across geographical origins, with Iranian samples showing the widest range of T1 values, while Russian and some Iranian samples exhibited dual T2 components. LF NMR relaxation parameters (T1, T2) are strongly dependent on the geographic origin and molecular structure of Shilajit. The technique shows promise for use in authentication and traceability of Shilajit, enabling differentiation based on relaxation signatures.
Association between PM10 air pollution and birth weight after full-term pregnancy in Krakow city 1995–2009 – trimester specificity
(http://www.aaem.pl/, 2015) Merklinger-Gruchała, Anna; Kapiszewska, Maria
Introduction and objective. The results of epidemiological studies indicate that the higher maternal exposure to air pollution, especially with particulate matter during pregnancy, the lower the infant’s birth weight. The aim of this study was to estimate entire pregnancy and trimester-specific exposure of pregnant women in the city of Krakow, southern Poland, to fine particulate matter [≤10 μg (PM10)], and to assess its effect on the birth weight of boys and girls separately. Material and methods. The study group consisted of 85,000 singleton, live, full-term births in Krakow city during a 15-year period (data from the birth registry). The mean concentrations of the pollutant for each month of gestation were estimated using continuous municipal monitoring data. Results. Multiple linear regression analyses indicated that the mean PM10 concentration during entire pregnancy was inversely associated with birth weight in girls and the group of boys and girls combined, after adjusting for maternal age, gestational age and year of birth; in boys the relationship was not statistically significant. Maternal exposure to PM10 during the first trimester was negatively associated with birth weight separately in girls and boys, and the group of boys and girls combined. However, the PM10 exposure during the second and third trimester of pregnancy was not associated with birth weight. Conclusions. PM10 air pollution at levels currently encountered in Krakow city adversely affect infant birth weight; however, the effect seems to be very small. The influence of particulate air pollution on foetal growth in early gestation is one of several possible explanations for the results, but further research is needed to establish possible biological mechanisms explaining the observed relationship.
Caregiver Burden and Support for People with Neurological Disorders: Findings from a Polish Cross-Sectional Study
(Licensee MDPI, Basel, Switzerland, 2026-01-14) Pasek, Małgorzata; Strzesak, Zofia; Goździalska, Anna; Jochymek, Małgorzata
Abstract "Neurological diseases are a major cause of long-term disability and dependence. In Poland, as in many countries, informal caregivers provide most longterm care for individuals with chronic and progressive neurological conditions. Although essential, this role is associated with substantial physical, psychological, and social burden. This study aimed to assess the scope and nature of support provided by caregivers to people with neurological diseases and to identify factors associated with differences in support and caregiver burden. Methods: A cross-sectional quantitative study was conducted using a CAWI survey. The sample included 104 informal caregivers of adults with various neurological conditions. An author-designed questionnaire and the “Actually Provided Support” subscale of the Berlin Social Support Scales (BSSS) were used. Nonparametric statistical tests were applied (p < 0.05). Results: Caregivers provided a high level of support, particularly emotional and instrumental support, while informational support was less intensive. Women more frequently reported high emotional and instrumental support. Higher buffering–protective support was more common among caregivers aged over 45 years. The most frequently reported difficulties were psychological fatigue (70.9%) and physical fatigue (60.2%), indicating a substantial caregiving burden. Key barriers included limited access to reimbursed healthcare services and the lack of temporary replacement in caregiving. Caregivers most often indicated the need for respite care and better access to information and education. Conclusions: Informal caregivers play a crucial role in the daily functioning of people with neurological diseases, despite high burden and insufficient systemic support. Expanding respite care, improving access to information, and better coordination of healthcare services are urgently needed."(...)
Changes in morphological and cytological properties of blood during physical exercise in water at 4oC and 25oC
(Wydawnictwo Akademii Wychowania Fizycznego w Krakowie, 2011) Teległów, Aneta; Bilski, Jan; Dąbrowski, Zbigniew; Marchewka, Anna; Jaśkiewicz, Jerzy; Głodzik, Jacek; Kępińska, Magdalena; Lizak, Dorota
Objective: The aim of this study was to determine the effect of a single swimming exercise till exhaustion, in water on the morphological and cytological blood parameters in laboratory rats. Methods: The experiment involved 60 male rats from the Wistar strain, aged 8 weeks and 36 weeks. The animals were separated into 6 groups: 3 groups (I, II, III) of 8-week old animals, and 3 groups (IV, V, VI) of 36-week old animals. The rats in the study groups i.e. II, III, V, and VI were made to swim till exhaustion in water at 4ºC and at 25°C. After the experiment blood samples were collected from each rat and hematological and cytological determinations were completed for each sample. Results: Compared with the control group, in the rats from group II (8-week old, swimming in water at 4ºC) a significant increase was noted in the RBC count, Hb, Ht, and MCHC, and MCH indices, whereas in the rats from group V (36-week old, swimming in water at 4ºC) increases were noted in the MCHC and MCH indices (again when compared with the control group). In the rats from group III (8-week old, swimming in water at 25ºC), compared with the control group, significant increases were noted in the Hb and Ht parameters, as well as in the MCHC, and MCH indices, whereas in the group VI rats (36-week old swimming at 25ºC) – the increase was noted in the MCHC index. No alterations were found in the reticulocyte count, and in poikilocytes during exercise in water at low temperatures in either the 8-week or 36-week old rats. Conclusions: The increases in the majority of blood parameters, testifies to the dehydration of the body during physical exercise which in turn affects the microcirculation function. The lack of alterations in the reticulocyte count in the peripheral blood may, in turn, testify to the ineffectiveness of low temperature during exercise upon the function of the bone marrow.
Clinical review of physical therapy intervention for ataxia
(Radomska Szkoła Wyższa, 2013) Grygus, Igor; Romanyshyn, Mykola
In the article the clinical activity of a physical therapist for patients with ataxia. Analyzed the causes of ataxia, physical examination of patient and rehabilitation interventions in this pathology. Ataxia – (from the Greek α- [means denying] and τάξις order) means a violation of the coordination of voluntary movement, is a neurological symptom. Ataxia is a non-specific clinical manifestation, which indicates that the dysfunction of the nervous system, namely the ability to co-ordinate voluntary motions (for example, cerebellum). Codes of the International classification of functions, disability and health (ICF): b750 (Motor reflex functions), b755 (Involuntary movement reaction functions), b760 (Control of voluntary movement functions), b765 (Involuntary movement functions), b770 (Gait pattern functions). Various means of physical therapy efficiency are confirmed by international surveys of scientific and evidence-based practice, namely: approaches to improve proprioceptive, measures to improve balance, vestibular exercises, approaches to minimized limb ataxia and the use of supportive aids. Separately considered rehabilitative interventions to improve gait in patients with ataxia. Conclusion. The on top of mentioned elements of the physical therapy intervention to help the physical therapist to reduce signs of ataxia and minimize the limited opportunities, which arises as a result of this dysfunction.
Comparative multi-analytical characterization of lipid fractions from three cockroach species - Blaptica dubia, Gromphadorhina portentosa, and Periplaneta lateralis
(Elsevier, 2026-04-11) Kowalczewski, Przemysław Łukasz; Kucharski, Jan Jakub; Ostrowska-Ligęza, Ewa; Grygier, Anna; Kmiecik, Dominik; Kamińska, Wiktoria; Siger, Aleksander; Dwiecki, Krzysztof; Siejak, Przemysław; Radzikowska-Kujawska, Dominika; Baranowska, Hanna Maria
This study presents a comprehensive, multi-analytical characterization of lipid fractions extracted from three cockroach species: Blaptica dubia, Gromphadorhina portentosa, and Periplaneta lateralis, with the aim of elucidating interspecies differences in fatty acid composition, molecular organization, and physicochemical behavior. Lipid fractions were analyzed using gas chromatography, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), low-field nuclear magnetic resonance (LF NMR) relaxometry, and Langmuir monolayer techniques. All oils were dominated by monounsaturated fatty acids, particularly oleic acid; however, marked differences were observed in the SFA/MUFA/PUFA balance, iodine values, thermal transitions, and interfacial properties. B. dubia oil exhibited the most balanced fatty acid profile and the most compact and viscoelastic monolayers, indicating a structurally stable lipid system. G. portentosa oil was characterized by the highest tocopherol content and enhanced oxidative resistance, whereas P. lateralis oil showed the highest degree of unsaturation accompanied by increased molecular mobility. The applied analytical techniques revealed distinct lipid structuring and stability patterns across species, demonstrating that cockroach-derived oils represent chemically and structurally diverse lipid matrices. These findings provide fundamental physicochemical insight into insect-derived lipids and establish a reference framework for future studies addressing technological performance, stabilization strategies, or regulatory assessment pathways.
Composition and Biological Properties of Agaricus bisporus Fruiting Bodies – a Review
(http://journal.pan.olsztyn.pl, 2017) Muszyńska, Bożena; Kała, Katarzyna; Rojowski, Jacek; Grzywacz, Agata; Opoka, Włodzimierz
White Agaricus bisporus is both the most popular and the most commonly eaten edible mushroom species in the world. It is popular not only because of its taste, but also due to its high level of nutrients: dietary fiber (chitin), essential, semi-essential amino acids, unsaturated fatty acids including linoleic and linolenic acids, easily digestible proteins, sterols, phenolic and indole compounds, and vitamins − especially provitamin D2 and B1, B2, B6, B7, and C. Fruiting bodies of A. bisporus have antioxidant, antibacterial, anti-inflammatory, antitumor, and immunomodulatory activity. The presence of antioxidant ergothioneine (which also displays the antimutagenic, chemo- and radioprotective activity) is also noteworthy. A. bisporus also contains derivatives of benzoquinone, a substance which belongs to the group of antibiotics. Studies of tyrosinase isolated from this species show its very high similarity to human tyrosinase. This points directly to the fact that this species could be a rich source of tyrosinase used for medicinal and cosmetics purposes. A. bisporus is also a rich source of selenium, zinc and other elements such as magnesium, copper, iron, potassium, sodium, calcium, phosphorus, sulfur or manganese. In conclusion, the presence of these compounds and elements with biological activity in fruiting bodies of A. bisporus confirms their nutraceutical and medicinal properties.
Dawstwo i transplantacje narządów w opinii studentów pielęgniarstwa studiów uzupełniających pomostowych
(Wydawnictwo Czelej, 2012) Romanowska, Urszula; Lizak, Dorota; Jaśkiewicz, Jerzy; Lipińska, Maria
Transplantacje są uznaną metodą terapeutyczną i szansą na powrót do zdrowia dla wielu chorych. Dla transplantologii ważne są uregulowania prawne, które umożliwiają pobranie narządów do przeszczepu od osób, po ich śmierci. W Polsce obowiązuje zasada zgody domniemanej na pobranie narządów lub tkanek do transplantacji Zgodnie z prawem, za moment śmierci przyjmuje się orzeczenie śmierci mózgu, jako rzeczywistej śmierci człowieka. Pomimo, że transplantacja, jako metoda leczenia zyskała powszechną aprobatę, wymienione uregulowania prawne nie są przez wszystkich akceptowane, bowiem spotykają się zarówno z krytyką jak i sprzeciwem. Cel pracy. Celem badań było poznanie opinii i postaw studentów pielęgniarstwa studiów uzupełniających pomostowych, wobec dawstwa i transplantacji narządów pobranych od dawców żywych, spokrewnionych jak i osób uznanych za zmarłe w wyniku orzeczenia u nich śmierci mózgu. Metoda i materiał. W badaniach zastosowano metodę sondażu diagnostycznego, jako technikę wykorzystano kwestionariusz ankiety własnej konstrukcji. Badaniami objęto grupę 100 osób, pielęgniarek/pielęgniarzy, studentów studiów pomostowych, kierunku pielęgniarstwo, pracujących w zakładach opieki zdrowotnej na terenie Małopolski. Badania przeprowadzono w maju 2012 roku.
Enhanced nutritional value of mung bean microgreens compared to sprouts: a quantitative study
(De Gruyter, 2026-02-19) Marottickal, Sheba Sunny; Saji, Neethu; Valattil, Noufan; Sajeev, Sudharsh; Surendran, Theertha; Kuriakose, Ritty; Syamala, Athira; Ivanišová, Eva; Nowicki, Marcin; Kowalczewski, Przemysław Łukasz
Abstract: "Microgreens, the young edible seedlings of vegetables and herbs, have emerged as nutrient-rich alternatives in contemporary diets due to their enhanced sensory and nutritional attributes. This study investigates the nutritional composition and microbial quality of mung bean microgreens in comparison to mung bean sprouts. A consumer perception survey conducted via social media revealed that while awareness of microgreens’ health benefits is relatively high, actual consumption remains limited. On a fresh‑weight basis, microgreens showed lower protein and fat contents but nearly double the dietary fiber content compared to sprouts. Microgreens also exhibited elevated levels of essentialminerals such as calcium, magnesium, iron, and zinc, with a slight reduction in potassium content. Furthermore, a significant increase in ascorbic acid (p < 0.05) was observed, whereas chlorophyll content showed no notable difference (p > 0.05). These findings suggest that mung bean microgreens may serve as a superior functional food component, offering a convenient, sustainable option to increase dietary fiber, selected minerals, and vitamin C in modern diets."(...)
High tea consumption diminishes salivary 17beta-estradiol concetration in Polish women
(Cambridge University Press, 2006) Kapiszewska, Maria; Miśkiewicz, Małgorzata; Ellison, Peter T.; Thune, Inger; Jasieńska, Grażyna
We hypothesized that among reproductive-age women consuming large quantities of tea, the production of estradiol would be suppressed. It has been shown that catechins and theaflavines, the major constituents of tea, inhibit aromatase, an enzyme which catalyses the conversion of androgens to estrogens. Our study included Polish women living in urban (N=61) and rural (N=48) areas. Women collected daily saliva samples for one complete menstrual cycle and filled out dietary questionnaires. Saliva samples were analyzed by radioimmunoassay for concentration of 17-β estradiol (E2). Women with high (above the median) average daily consumption of black tea had reduced levels of salivary E2, in comparison with women who drank less black tea (below median). This effect was observed within the whole study group, as well as separately within urban (p = 0.0006) and rural (p = 0.013) groups. High intake of the sum of subclasses of tea catechins and epigallocatechin gallate, assessed using the USDA database [http://www.nal.usda.gov], was also associated with lower concentrations of E2 within all women (p = 0.01 and p = 0.0001, respectively) and within the urban group (p = 0.0001 and p = 0.004, respectively). Similar relationships were observed between the sum of subclasses of theaflavines and thearubigines and E2 levels for the whole group (p = 0.002) and for urban women (p = 0.02). Women with high consumption of tea had lower levels of E2 concentration throughout the entire menstrual cycle. These results may have implications for reducing hormone-related cancer risk by a relatively easy dietary intervention.
Improving physical performance in children with congenital clubfoot
(Medical Project Sp. z o.o., 2013) Mykhaylova, Nataliya; Grygus, Igor
Introduction. Pre-school period is one of the most crucial periods of human life in the formation of physical health and cultural skills to ensure the improvement, strengthening and preserving the futurę. Materials and ntethods. The study involved 68 pre-school children with congenital clubfoot: control group 1 (n = 34) and main group (n = 34) and healthy children (n = 34), who are the control group 2. At the beginning of the study the average age of children was 4-5 years. Children of the main group were constantly engaged in physical rehabilitation under the developed program. Participants of the control group were massaged and had a medical gymnastics twice a year. Results. The study improved physical performance in the main group: high at 14,71%, good in 52,94%, 32,35% in average. There was no significant increase in physical performance in the control groups. In the control group (number 2) good physical performance in the beginning of the study was 32,35% and it increased to 41,18% at the end of the study. In the control group (number 1) a good physical performance was at the beginning of 26,47%, and went up to 29,41%. Minor improvement of physical performance in children of control groups may have occurred even by reducing heart rate at rest. Conclusion. Average physical performance in the main group at the end of the study was 5,76±0,28 (p<0,05), corresponding to a good level of physical performance and demonstrates the effectiveness of the use of physical rehabilitation.
Membranous E-Cadherin Expression in Different Subtypes of Pituitary Neuroendocrine Tumors and Its Association with Invasiveness
(MDPI, 2026-03-14) Krzentowska, Anna; Biesaga, Beata; Merklinger-Gruchała, Anna; Gołkowski, Filip
Pituitary neuroendocrine tumors (PitNETs) are usually benign intracranial neoplasms that may exhibit invasion of the cavernous sinus, complicating surgery and increasing the risk of recurrence. This study aimed to investigate membranous E-cadherin (mE-cad) expression across PitNET subtypes and transcription factor (TF) lineages, including Pit-1 (pituitary-specific positive transcription factor 1), SF-1 (Steroidogenic Factor 1), and TPIT (T-box pituitary transcription factor), and its association with tumor invasiveness in sixty-nine patients. mE-cad expression was evaluated as the percentage of positive cells (0%, 1–10%, >10%) and by immunoreactive score (IRS). Staining intensity was scored as: 0, no staining; 1, weak; 2, moderate; 3, strong. The proportion of positive cells was scored as: 0, none; 1, <10%; 2, 10–50%; 3, 51–80%; 4, >80%. Mean mE-cad expression was 5.2% in gonadotroph, 3.2% in corticotroph, 0.5% in lactotroph, and 17.5% in plurihormonal PitNETs. By TF lineage, the mean expression was 5.3% for Pit-1, 3.2% for TPIT, and 5.1% for SF-1. Low mE-cad expression (IRS 1–2) was associated with higher odds of cavernous sinus invasion compared with IRS 3–6 (adjusted OR = 6.0, 95% CI 1.08–33.4, p = 0.04), independent of tumor volume (adjusted OR = 4.0, 95% CI 1.50–10.7, p = 0.01). After restricting the analysis to the gonadotroph PitNET group, tumors with an IRS of 1–2 showed significantly higher invasiveness compared with those with an IRS of 3–6 (p = 0.012). These findings suggest that mE-cad may serve as a biomarker of PitNET invasiveness, with expression varying according to TF lineage and tumor subtype.
Moulding of professional and personal features of a character of future specialists on health
(2015) Grygus, Igor; Prusik, Krzysztof
The following article is studding and considering the results of the research work on the subject matter: personal example on the part of specialists on health in their activities in institutions of physical rehabilitation as well as their acquiring both physical and personal features of a character by the virtue of traditional Vedic (ancient Indian) knowledge such as Ayurveda and BhagavataPurana, which in turn contain some practical recommendations pertaining to support of health and development of consciousness on the basis of profound unity both of spiritual, psychological as well as physical state of a person.
Optymizing the level of physical health of students by type of autonomic nervous system
(Radomska Szkoła Wyższa, 2013) Grygus, Igor; Kuczer, Tetyana
We analyzed changes in the physical health of students of the Faculty of Physical Education under the influence of physical training by type of autonomic nervous system. In the study, 87 students attended the first and second year of study. The basis of the impact was the principle of individualized physical activity, regularity and gradualness. It was found that by including the autonomic nervous edge-type system, a much higher level of physical health indicators at the end of the study were the students' main group, in which the overall assessment of the level of physical health above average level reached in principle at the expense of improving the life, strength and index Robinson.
Peripheral complement C3 and C4 are associated with clinical features of schizophrenia
(Frontiers, 2026-03-30) Szwajca, Marta; Śmierciak, Natalia; Biesaga, Beata; Donicz, Paulina; Szwajca, Krzysztof; Pilecki, Maciej
Aim: Schizophrenia is a severe psychiatric disorder with heterogeneous outcomes; factors such as anxiety, childhood trauma, and duration of untreated psychosis (DUP) may influence symptom severity and disease progression. Growing evidence highlights immune dysregulation—particularly alterations in complement components C3 and C4—in the pathophysiology of schizophrenia; however, findings regarding peripheral complement levels and their clinical associations remain inconsistent. Method: Thirty-nine patients with schizophrenia underwent clinical assessment using the Childhood Trauma Questionnaire (CTQ), the Positive and Negative Syndrome Scale (PANSS), the State–Trait Anxiety Inventory (STAI), and the Montreal Cognitive Assessment (MoCA). Serum concentrations of C3 and C4 were measured at admission. Results: In exploratory analyses (nominal p-values), baseline C3 correlated with DUP (r=0.407, p=0.010) and length of hospitalization (r=0.353, p=0.028). Higher C3 was associated with greater symptom severity on PANSS-P1 (r=0.325, p=0.043) and PANSS-G1 (r=0.330, p=0.040), while C4 correlated with PANSSG1 (r=0.322, p=0.045) and multiple PANSS domains after 12 weeks. C3 was associated with anxiety at baseline and after 3 months (STAI-T1: r=0.376, p=0.018; STAI-S1: r=0.372, p=0.020; STAI-T2: r=0.376, p=0.018; STAI-S2: r=0.419, p=0.009), whereas C4 correlated with STAI-T1 (r=0.361, p=0.024), STAI-S1 (r=0.342, p=0.033), and STAI-S2 (r=0.338, p=0.038). Higher C3 and C4 levels were associated with CTQ subscales. C3 correlated negatively with cognitive performance (MoCA1: r=–0.339, p=0.034). However, none of the associations survived Benjamini–Hochberg false discovery rate (BH-FDR) correction (all q>0.05). Conclusion: These exploratory, within-cohort findings suggest that peripheral complement markers relate to variation in clinical severity and illness-course indicators in schizophrenia. Replication in larger, controlled longitudinal studies is warranted.
Plant-derived phenolic acids in Shilajit: a comparative HPLC–MS/MS analysis across five regions
(Nature Portfolio, 2026-02-16) Kamgar, Elham ; Spryszyńska, Aleksandra ; Zembrzuska, Joanna ; Kowalczewski, Przemysław Łukasz ; Kaykhaii, Massoud
Abstract: "Shilajit, a resinous exudate traditionally used in Asian medicine, is thought to originate from the decomposition of plant material, yet direct chemical evidence for this hypothesis has remained limited. Here, we report the first comprehensive quantification of phenolic acids, as the key plant-derived antioxidants, in eleven Shilajit samples from Iran, India, Nepal, Russia, and Kyrgyzstan using HPLC–MS/MS. Nine phenolic acids (gallic, vanillic, syringic, caffeic, p-coumaric, ferulic, sinapic, chlorogenic, and rosmarinic acids) were identified and quantified. Most samples had more hydroxybenzoic acids (gallic, vanillic, syringic) than hydroxycinnamic acids. Gallic acid was the most abundant compound, reaching up to 2839.28 μg g−1 in Iranian Shilajit, whereas rosmarinic acid displayed exceptionally high levels (216.26 μg g−1) in one Iranian sample. The pronounced geographical variation in phenolic acid composition suggests a strong environmental and botanical influence on Shilajit formation. These findings provide molecular evidence supporting its plant-based origin and highlight phenolic acids as contributors to Shilajit’s well-documented antioxidant and therapeutic effects. The study also establishes a robust analytical platform for future standardization and quality assessment of Shilajit as a natural medicinal product."(...)
Polepszenie poziomu fizycznego zdrowia studentów przy pomocy zaproponowanych ćwiczeń ruchowych z uwzględnieniem typu autonomicznego nerwowego systemu
(Radomska Szkoła Wyższa, 2013) Grygus, Igor; Prusik, Krzysztof; Prusik, Katarzyna
Level of physical education in high school is not conducive to the effective reduction of the deficit of motive activity of students, which is one of the reasons various deviations in their health. The health of young people is essential and defining moment of well-being of society and its progressive development. The basic principle of the impact physical activity core group of students with different types of autonomic nervous system was the principle of individualization of physical activity, not dropping the weights regularity and consistency. The load volume was optimal, at the level of preparedness that much depended on the type of dominance of the autonomic nervous system. All students conducted a rapid assessment of the overall level of physical health by Apanasenko G.L. at the beginning and end of the study. With the prevalence of type counting of the autonomic nervous system, significantly higher levels of physical health were found among students at the end of the study the main group in which the overall assessment of physical health reached a level above the average.
Promocja zdrowia - realizm czy utopia?
(Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, 2015) Lizak, Dorota; Seń, Mariola
Dziedziną, która w ciągu ostatnich lat osiągnęła znaczny stopień popularności w skali globalnej jest promocja zdrowia. Wynika to nie tylko z jej historii (choć stosunkowo krótkiej) czy dorobku, ale działań podejmowanych na jej płaszczyźnie i niejednokrotnie bardzo dobrych efektów tych działań. Współczesne trendy zdrowotne jak i statystyki dotyczące zachorowalności czy umieralności wskazują na konieczność realizowania zadań z zakresu promocji zdrowia, bowiem tendencje te wynikają w dużej mierze z niewłaściwego czy też nieracjonalnego stylu życia jednostek, a często również z deficytu wiedzy. Aby jednak uczynić go bardziej racjonalnym, potrzebna jest wiedza upowszechniana przez profesjonalistów, tj. osoby merytorycznie przygotowane do jej krzewienia. Promocja zdrowia nie jest jedynie ideą, która ma zapełniać niszę w naukach o zdrowiu, ale przez lata wdrażania i kultywowania pewnych zasad i przekonań, wynikających z doświadczeń i obserwacji, okazuje się być inicjatywą przynoszącą wymierne korzyści. Przegląd rozpowszechnionych i coraz bardziej popularyzowanych zagadnień zdrowotnych w mediach pozwala na stwierdzenie, że zdrowie i jego umacnianie staje się tematem modnym. W związku z powyższym, aby móc istnieć we współczesnych realiach należy mieć świadomość procesów i stanów rzeczy jakie dzieją się wokół jednostki. Dlatego też promocja zdrowia stanowi integralną część zdrowia publicznego, zaś człowiek, będąc częścią społeczeństwa, partycypuje własnym zdrowiem w zdrowiu zbiorowości, stanowiąc jej podmiot składowy. Przyczyniając się jednak do jego budowania, powinien posiadać elementarną wiedzę o tej niematerialnej wartości.

Przeglądaj

Przeglądaj 1.2 Artykuły z wydawnictw zewnętrznych wg Temat "Medycyna"

Wyników na stronę

Opcje sortowania